Use QuickStitch™ Hole 
to cut out holes within the currently selected fill area automatically, by clicking in the required color areas of the picture. If required, use Color Tolerance to select a larger area according to the similarity of adjacent colors.
This is useful to cut out holes in an existing fill area with a background picture.
Also use QuickStitch™ Hole 
to create specific holes that were not previously removed. For example, some holes you wanted may have been included in the fill area because of the Color Tolerance setting.
Shortcuts
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Quick Create Tab, Enhance:
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Keys: Alt, Q, U
Create a Hole in a Fill Area Automatically
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Click in the fill area in which you want to create a hole.
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Click QuickStitch™ Hole
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Click in a defined color area within the fill area to cut out a hole.
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Repeat to create more holes, as desired.
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Right-click to deselect, or simply select another Create tool.