Use the Hole functions QuickStitch™ Hole 
, Freehand Hole 
 and Point Hole 
 to create holes in existing fill areas.
Alternatively, use QuickStitch™ + AutoHole 
 to add holes automatically during fill creation. 
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    Fill Area with holes using Pattern Fill 111 from Hearts  | 
   
    Fill Area with holes using Motif Fill Pattern 6 from General Motifs 1  | 
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    Fill Area with Satin border and holes using Motif Fill Pattern 6 from General Motifs 1  | 
   
    Fill Area with Satin border and holes using Pattern Fill 109 from Hearts  | 
Create Holes in a Fill
Click the desired area to select it.
In the Fill Area of the Create tab, click the desired Hole function.
Choose from QuickStitch™ Hole 
, Freehand Hole 
 and Point Hole 
.
Cut the hole using the selected hole function.
Repeat to create more holes, as desired. Right-click to deselect, or simply select another Create tool.